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Guayusa (Ilex guayusa) is a holly tree native to the Amazon rainforest. People have harvested this tree’s leaves since ancient times due to their perceived health benefits, including antioxidant and anti-inflammatory properties (1Trusted Source). Today, guayusa beverages like tea are becoming increasingly popular. Still, you may wonder whether its benefits are backed by science — and whether it has any side effects. This article examines the uses, benefits, and side effects of guayusa. What is guayusa? Guayusa trees can grow 19–98 feet (6–30 meters) tall and produce bright green, oblong leaves. Although found throughout the Amazon rainforest, this species is most widely cultivated in Ecuador (2Trusted Source). Traditionally, its leaves are picked, dried, and brewed to make herbal tea. Today, it’s also sold as a powder and extract — and added to products like energy drinks and commercial teas. Guayusa contains significant concentrations of caffeine and is a rich source of antioxidants and other beneficial plant compounds (1Trusted Source). SUMMARY Guayusa is native to the Amazon rainforest and harvested primarily in Ecuador. Its leaves are typically brewed to make tea and touted for their caffeine and antioxidant content. ADVERTISEMENT Try Amazon Elements Turmeric Complex for joint pain relief Fight off inflammation with high-quality, natural ingredients — at a low price. Amazon Elements Turmeric Complex provides an affordable way to support your immune system. Potential benefits and uses of guayusa While research is limited, guayusa may provide several health benefits. May improve mood and concentration Guayusa packs an impressive punch of caffeine, a known stimulant. In fact, it offers similar amounts of caffeine as regular coffee (3Trusted Source). In addition, it contains theobromine, an alkaloid that’s structurally similar to caffeine. Theobromine is also found in foods like chocolate and cocoa powder (4Trusted Source). In combination, caffeine